Endocrine complications may be seen in thalassemia major patients due to iron overload or deficient chelation regimens. IGF-1 and ferritin levels were evaluated in 68 beta-thalaasemia major patients in the ages of 2-29 years for growth retardation. The patients were composed of 43 males and 25 females. The man age of total population was 15.04±6.57 years. The mean of ferritin was 1499.67±1471.50ng/ml.

The mean of IGF-1 was 130.90±97.64. The correlation coefficient for ferritin and IGF-1 for Pearson was -2.47 (Figure 1). This finding shows us negative correlation between ferritin and IGF-1 levels. Most of the patients were in adolescent ages and it shows us scheduled follow-up visits for endocrine complications are very important. Among this patients , 2 patients were taking growth hormon.

Figure 1
Figure 1.
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Disclosures

No relevant conflicts of interest to declare.

Topics:
cooley's anemia, insulin-like growth factor i, ferritin, ferritin measurement, growth retardation, iron overload, adolescent

Author notes

*

Asterisk with author names denotes non-ASH members.

© 2017 by The American Society of Hematology
2017
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